This retrospective study compared the rates and visual outcomes of post–intravitreal injection endophthalmitis in eyes pretreated with 5% povidone–iodine versus 0.05% chlorhexidine. Notably, there was no significant difference in endophthalmitis rate or visual outcomes between the two treatment groups. In addition, the use of prefilled syringes was associated with a significant reduction in endophthalmitis rate. These findings provide clinically useful information on the potential factors contributing to the variable rates of post–intravitreal injection endophthalmitis.

Samuel Asanad MD

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